Increased expression of heat shock protein 90 in keratinocytes and mast cells in patients with psoriasis - 14/03/14
, Nikhil Yawalkar, MD aAbstract |
Background |
Psoriasis is a chronic inflammatory skin disease and various stress factors mediate inflammation. Heat shock protein (HSP) 90 plays an important role in cell survival; cytokine signaling, such as interleukin-17 receptor signaling; and immune responses.
Objective |
We sought to elucidate protein expression and distribution of HSP90 in psoriasis.
Methods |
HSP90 expression and its cellular source were analyzed on normal-appearing, nonlesional, lesional, and ustekinumab-treated psoriatic skin using immunohistochemistry and double immunofluorescence.
Results |
HSP90α, the inducible isoform of HSP90, was significantly up-regulated in epidermal keratinocytes and mast cells of lesional skin and down-regulated after ustekinumab therapy.
Limitations |
There was a limited sample size.
Conclusions |
HSP90 from keratinocytes and mast cells is a key regulator of psoriatic inflammation and HSP90 inhibitors may represent a novel therapeutic approach to the disease.
Le texte complet de cet article est disponible en PDF.Key words : heat shock protein, heat shock protein 90, heat shock protein 90 inhibitor, keratinocytes, mast cells, psoriasis
Abbreviations used : DC, HSP, IL, MC, Th17
Plan
| Supported by a grant from the Hans Stettler Foundation and the Fondation de France. |
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| Disclosure: Dr Yawalkar has served as a consultant and received research trial support from Janssen Cilag AG. Drs Kakeda, Arock, and Schlapbach have no conflicts of interest to declare. |
Vol 70 - N° 4
P. 683 - avril 2014 Retour au numéro
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